WebSep 1, 2003 · Two injections of an agonistic CD28 antibody were shown to dramatically accelerate repopulation of T cells, and the resulting T cells had a broad repertoire and were functional, suggesting that treatment with human CD28–specific agonists could protect T-lymphopenic patients from opportunistic infections. CD28 ligation by natural ligands … WebThe main effect of anti-CD28 superagonist antibodies is the expansion of T reg populations. These antibodies are therefore effective in the treatment of autoimmunity models (i.e., diabetes, arthritis, and glomerulonephritis) and the prevention of organ rejection following transplantation [129].

T Cell Activation via Anti-CD3 and Anti-CD28 - Thermo Fisher Scientific

WebThe CD28.2 monoclonal antibody specifically binds to CD28, a 44 kDa homodimeric transmembrane glycoprotein present on most mature T cells, thymocytes and plasma cells. CD28 is a costimulatory receptor that … WebRecombinant monoclonal antibody to CD28. TGN1412 is a humanized antibody that can be potentially used in the treatment of inflammatory diseases, autoimmune diseases. … dr koo jurong point

Anti-Human CD28 Recombinant Antibody (TGN1412)

WebMar 30, 2024 · Fc mutations were made in the IgG4-based TGN1412 anti-CD28 mAb to define the role of FcγR interactions in its “super-agonist” activity. The dual mutation, IgG4-ED 269,270 AA, ablated interaction with all human FcγR and agonistic action was consequentially lost, confirming the FcγR-dependence on the action of TGN1412. WebThe CD28 Bioassay is a bioluminescent cell-based assay used to measure the potency and stability of ligands or antibodies that activate CD28. CD28 binds to the B7 family members CD80 and CD86 (collectively referred to as B7 for … WebOptional: Add Human CD28 Activating (CD28.2) Mouse mAb (Low Endotoxin, Azide-free) #91920 to cells at 1:200 to reach a final concentration of 10 µg/ml. Keep cells with … random japanese anime name generator