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Cisplatin pathway

WebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI. WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …

Inhibition of GLUT-1 expression and the PI3K/Akt pathway to …

WebCisplatin (CP), cis-diamminedichloroplatinum(II), is a potent anti-tumor agent extensively used in cancer therapy, but its frequent application leads to the development of … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying … dojencek noce jesti mesa https://groupe-visite.com

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WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ... reacts with the 26S proteasome complex and enhances DUB in the proteasome 19S ... WebMar 1, 2024 · Cisplatin represents a potent chemotherapeutic molecule with wide use in a broad spectrum of malignant diseases1. Unfortunately, ototoxicity, neurotoxicity, and nephrotoxicity are serious undesirable effects of cisplatin that quite limit its application2. WebApr 15, 2024 · A 64-year-old man exhibited lack of efficacy during treatment with pirarubicin, gemcitabine and cisplatin for metastatic, high-grade non-muscle invasive bladder … pure\\u0026good

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Cisplatin pathway

Nrf2 signaling pathway in cisplatin chemotherapy: …

WebMar 22, 2024 · This study aims to identify pathway involvement in the development of cisplatin (cis-diamminedichloroplatinum (II); CDDP) resistance in A549 lung cancer (LC) cells by utilizing advanced... WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared.

Cisplatin pathway

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WebDec 9, 2024 · Cisplatin is the first-line drug for postoperative chemotherapy in OSCC patients; however, >30% of patients are initially insensitive to platinum-based chemotherapy, and the rest gradually become... WebNational Center for Biotechnology Information

WebOct 13, 2024 · Cisplatin is an inorganic platinum derivative that is widely used for chemotherapy of various solid tumours. In cancer cells, cisplatin induces DNA crosslinks and DNA adducts, triggering the... WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.

WebMar 20, 2024 · Cisplatin (CDDP) is a platinum-based antitumor drug [ 1 ]. Its widespread use in the treatment of breast cancer, ovarian cancer, and other cancers has greatly improved the survival rate of patients [ 1 – 4 ]. However, this process is often accompanied by serious side effects, including nephrotoxicity and ototoxicity [ 5 ]. WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as …

WebSep 18, 2024 · National Center for Biotechnology Information

WebCisplatin (DDP) was reported to improve pathological complete response (pCR) rates in triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still remains largely unknown. Emerging evidence suggested that some chemotherapeutic drugs played anti-tumor effects by inducing cell pyroptosis. pure tone mono jackWebLy3214996, an inhibitor of ERK signal pathway, was administered to assess the effects of BANCR overexpression on gastric cancer cell with cisplatin-treated resistance. Moreover, the role of BANCR in cisplatin resistance of gastric cancer was validated in xenograft mouse models in vivo. dojeni kravWebCisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and … dojenje beba po mjesecimaWebStandard chemotherapy for newly diagnosed ovarian cancer is a platinum–taxane combination. The Gynecologic Oncology Group conducted a randomized, phase 3 trial that compared intravenous ... dojenje alergija na jagodepure\u0027s broadview ilWebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, … dojenje bebeWebApr 28, 2006 · The FA/BRCA pathway regulates the cellular response to cisplatin and other DNA cross-linking agents ( 16 ). The pathway is governed by the coordinate activity of several FA proteins. In response to cross-linkers, a protein complex composed of at least eight FA proteins (A, B, C, E, F, G, L, M) monoubiquitinates the FANCD2 protein ( 17 – 19 ). pure tone jack 交換