Cisplatin renal injury

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August undefined, 2024

WebHumphreys, Benjamin D. / Caught in the crossfire : cancer, cisplatin therapy, and kidney injury.In: American journal of physiology. Renal physiology. 2024 ; Vol. 324 ... WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in …

Impact of cisplatin-induced acute kidney injury on long …

WebMar 29, 2024 · Cisplatin-Induced Acute Kidney Injury: Role of the Immune System . Inflammatory pathways have been linked to major pathophysiological mechanisms … WebSep 2, 2024 · Acute kidney injury (AKI) is a common complication that accounts for death in patients with sepsis, and the incidence of AKI is increasing year by year. ... MLT alleviates cellular apoptosis after kidney injury caused by cisplatin, inhibiting the NF-κB–mediated inflammatory response and RIPK1/RIPK3 complex–mediated necroptosis (Kim et al ... novak djokovic country of origin

Neferine mitigates cisplatin-induced acute kidney injury in mice …

WebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various intracellular stresses,... WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. … WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … how to slice roma tomatoes

Exploring the Metabolic Differences between Cisplatin- and UV …

Cisplatin nephrotoxicity: new insights and therapeutic implications ...

WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in the glomerular filtration rate, the elimination of cisplatin is delayed in patients with cancer, and, as a result, tubular and glomerular injuries subsequently develop. WebIntroduction. Cisplatin is an extensively used chemotherapeutic drug for various types of human cancer. However, 20–35% of patients are diagnosed with renal dysfunction after … novak djokovic net worth 2019 on forbesWebSep 15, 2024 · Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. how to slice roast lamb

"WebApr 1, 2024 · Acute kidney injury (AKI) remains a major global healthcare problem, and there is a need to develop human-based models to study AKI in vitro. Toward this goal, … " - Cisplatin renal injury

Cisplatin renal injury

WebDec 21, 2024 · Acute kidney injury (AKI) is an ominous clinical–pathologic state associated with the abrupt loss of renal functions and consequential complications. It is estimated that more than 20–50% of hospitalized patients are affected by various episodes of AKI [ 1 ]. WebJul 31, 2014 · Although the severity of cisplatin-induced nephrotoxicity is reduced following genetic or pharmacologic knockout of Oct1 and Oct2, renal tubular damage is not completely abolished. This suggests the existence of a secondary pathway that contributes, independently of Oct1/Oct2-mediated renal tubular drug uptake, to cisplatin-induced …

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WebFeb 1, 2024 · Cisplatin-Induced Kidney Injury: Delivering the Goods 2024 Feb;33 (2):255-256. doi: 10.1681/ASN.2024121591. Authors Joshua N Curry 1 , James A McCormick 2 … WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney …

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … WebAug 17, 2024 · Thirty percent of patients treated with cisplatin develop acute kidney injury, and all patients are at risk for long-term impacts on kidney function. There are currently no Federal Drug Administration-approved agents to prevent or …

WebOct 22, 2024 · We hypothesized that cisplatin, an anticancer drug that generally causes DNA damage and cell death in rapidly proliferating cells, exacerbates DNA damage in regenerative proliferating renal... WebApr 3, 2024 · As a result, renal injury is the most serious adverse effect restricting the application of cisplatin [ 4 ]. The prevalence of CP-induced acute kidney injury (CP-AKI) is approximately 31% to 68% in patients using cisplatin [ 5 ]. CP-AKI is characterized by tubular damage and acute renal dysfunction [ 6 ].

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WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney … novak djokovic official siteWebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … novak djokovic news the ageWebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney … how to slice runner beansWebJul 7, 2016 · This study presents data on renal outcomes across multiple tumor types in 821 adults. We report on incidence of AKI, initial and long-term changes in eGFR after … how to slice rump capWebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. … novak djokovic live stream federal court how to slice sausageWebJan 29, 2024 · Besides, pretreatment of paricalcitol could also alleviated Erastin (an inducer of ferroptosis) induced cell death in HK-2 cell. These data suggested that ferroptosis … how to slice samples in fl studio 20