WebDec 18, 2024 · Somatic loss-of-function mutations of the dioxygenase Ten-eleven translocation-2 (TET2) occur frequently in individuals with clonal hematopoiesis (CH) and … WebBy sensing the presence of cytosolic DNA, the recently described cGAS-STING pathway plays a central role in the defense against microbial invasions. 18 – 21 After binding to …
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY - MSigDB
Web28. Chen AY, Liu LF. DNA topoisomerases: Essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol 1994; 34:191-218. 29. Kaufmann SH. Cell death induced by topoisomerase-targeted drugs: More questions than answers. Biochim Biophys Acta 1998; 1400:195-211. 30. Walker JV, Nitiss JL. DNA topoisomerase II as a target for cancer … runoffs in texas
STING-dependent cytosolic DNA sensing pathway drives the …
WebTo ensure proper utilization of iron and avoid its toxicity, cells are equipped with iron-sensing proteins to maintain cellular iron homeostasis. We showed previously that NCOA4, a ferritin-specific autophagy adapter, intricately regulates the fate of ferritin; upon binding to Fe3+, NCOA4 forms insoluble condensates and regulates ferritin autophagy in iron … WebRecently, phase separation has been identified in different immune signaling pathways, of which cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling is an important innate immune pathway in DNA sensing and is tightly linked with pathological process including cancers, virus infection, and inflammatory diseases. WebThis proposal aims to investigate the role of cytosolic DNA sensing pathways in CD4 T cell differentiation.Cellular host defense to pathogens relies on the detection of pathogen … scdmh form m-450d