WebApr 4, 2024 · Vancomycin levels in this cohort were not associated with 30-day mortality (57/109, 52.3% of surviving patients had high vancomycin trough levels versus 24/53, 45.3% of patients who died, p = 0.402). Analysis of vancomycin levels/ MIC ratio also did not demonstrate a significant association with 30-day mortality ( Table 3 ). WebAchievement of serum unbound vancomycin trough concentrations at 4 to 5 times the MIC or 24-hour area under the concentration curve to MIC ratio of 400 was shown to be optimal for bacterial eradication and clinical success. 8-11 On the basis of 50% protein binding, a target vancomycin trough of 15 to 20 μg/mL will need to be achieved for MRSA ...

Association Between Vancomycin Area Under the Curve and …

WebTarget trough level: 10 – 15 mg/L (15–20 mg/mL for severe infections) Trough level samples are to be taken approximately 30 minutes before the dose is due. Inpatients with normal renal function, the next dose of vancomycin should be given at the scheduled time before the level is known. WebVancomycin has become a mainstay of therapy for treatment of pneumonia, osteomyelitis, septic arthritis, endocarditis, and other infections caused by methicillin-resistant … denver colorado weed dispensary

The association of vancomycin trough levels with outcomes …

WebFor culture-negative vertebral osteomyelitis associated with a surgical procedure, Vancomycin 1 g IV q 12 hours (goal trough 15-20 mg/L) should be given. If a spinal … WebJul 6, 2011 · minimum trough concentration would have to be at least 15 mg/L to generate the target AUC:MIC of 400." Meaning, trough goal of >10 is optimal tough except when … WebAug 15, 2011 · Vancomycin trough concentrations of 15 to 20 mcg per mL are recommended in patients with serious infections, such as bacteremia, infective endocarditis, osteomyelitis, meningitis, pneumonia, or ... denver combined sales tax rate