The primary ligand for P-selectin is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidans. PSGL-1 is situated on various hematopoietic cells such as neutrophils, eosinophils, lymphocytes, and monocytes, in which it mediates … See more P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated See more P-selectin is located on chromosome 1q21-q24, spans > 50 kb and contains 17 exons in humans. P-selectin is constitutively expressed in megakaryocytes … See more P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. When endothelial cells are activated by … See more • Selectin See more P-selectin is found in endothelial cells and platelets where it is stored in Weibel-Palade bodies and α-granules, respectively. In response to … See more P-selectin has a functional role in tumour metastasis similar to E-selectin. P-selectin is expressed on the surface of both stimulated … See more Crizanlizumab is a monoclonal antibody against P-selectin. which has now been approved by Novartis on November 15, 2024 for the indication of vaso-occlusive crisis in sickle cell patients. See more WebJul 1, 2024 · P-selectin, which is expressed on the surface of activated platelets and endothelial cells, activates platelets by interacting with the P-selectin glycoprotein ligand (PSGL)-1, which promotes...
Human P-selectin glycoprotein ligand-1 is a functional ... - Nature
WebAug 28, 2001 · P-selectin is a member of the selectin family of adhesion molecules. PSGL-1 on the plasma membranes of neutrophils or monocytes, which are key effector cells of the innate immune system, binds to P-selectin translocated to the surfaces of inflamed endothelial cells or activated platelets (Fig. 1 ). WebP-selectin glycoprotein ligand-1 (PSGL-1) is a dimeric mucin-like 120-kDa glycoprotein on leukocyte surfaces that binds to P- and L- selectin and promotes cell adhesion in the inflammatory response. cutting lexan
Two by two: The pairings of P-selectin and P-selectin glycoprotein ligand 1
WebNov 15, 2000 · The most characterized selectin ligand is P-selectin glycoprotein ligand-1 (PSGL-1), which was initially identified as a ligand for P-selectin, 8, 9 but is also reported to bind E- 10, 11, 12, 13 and L-selectins. 14 Gene-targeted mice, genetically deficient for PSGL-1 have been recently described. 15 Interestingly, these mice show defects in … WebNov 15, 2000 · The most characterized selectin ligand is P-selectin glycoprotein ligand-1 (PSGL-1), which was initially identified as a ligand for P-selectin, 8, 9 but is also reported … Webmonoclonal antibody (mAb) or anti–P-selectin glycoprotein ligand-1 (PSGL-1) mAb would reduce neointima formation in the setting of carotid denudation injury in atherosclerosis … cutting letters out of paper