Paprotrain discover
WebLearn more about Paprotrain ≥98% (by NMR). We enable science by offering product choice, services, process excellence and our people make it happen. WebNov 29, 2016 · Paprotrain, first inhibitor of MKLP-2 kinesin, is a micromolar inhibitor of DYRK1A. • One derivative of paprotrain was identified as a nanomolar inhibitor of DYRK1A. • Novel series of inhibitors of CDK5, GSK3, DYRK1A and CLK1 were synthesized. • We characterized three families of inhibitors with submicromolar to nanomolar IC 50. •
Paprotrain discover
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WebReversible inhibitor of MKLP-2 Shop Paprotrain, Tocris Bioscience™ at Fishersci.com Paprotrain, Tocris Bioscience, Quantity: 10 mg Fisher Scientific Fisher Scientific May 28, 2024 ·
WebDec 1, 2015 · In this regard, Paprotrain has been described as a potent inhibitor of KIF20A in HL60 (human myeloid leukemia cell line), leading to multinuclearity of these cells and … WebPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
WebPaprotrain is a reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (K i = 3.4 μ M). Inhibits the basal ATPase activity of MKLP-2 (IC 50 = 1.35 μ M). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable. WebFeb 15, 2016 · We have previously identified compound 1 (paprotrain) as the first selective inhibitor of MKLP-2. Herein we describe the synthesis and biological evaluation of new …
WebPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition …
WebNov 29, 2016 · Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors Further investigation of Paprotrain: Towards the … rigons crosshairWebMay 12, 2024 · A Leisurely Tour of Lake Arthur on Preston's Pearl. Preston's Pearl is named after the late Dr. Frank W. Preston whose conservation work led to the formation of the … rigoletto rotisserie and wine 東京スカイツリー店WebApplication: Paprotrain is a cell-permeable inhibitor of the kinesin-6 family member KIF20A (MKLP-2) CAS Number: 57046-73-8 Purity: ≥98% Molecular Weight: 245.28 Molecular Formula: C 16 H 11 N 3 For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. * Refer to Certificate of Analysis for lot specific data (including water content). rigor mortis and calciumWebThe MKLP-2 Inhibitor, Paprotrain controls the biological activity of MKLP-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. MKLP-2 Inhibitor, Paprotrain - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. SDS CoA References Data Sheet rigor chineseWebView and buy high purity Paprotrain from Tocris Bioscience, a Bio-Techne brand. Reversible inhibitor of MKLP-2. Skip to main content United States - (English) Country/Region selector. Please enter your country/region. Select Preferred Language. English. 简体中文 (800) 343-7475 ... rigor in educationWebPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM. Paprotrain has been screened on … rigor and trustworthinessWebPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition … rigor shortening