WebbTo examine the role of physiological Akt signaling in pathological hypertrophy through analysis of PHLPP1 (PH domain leucine-rich repeat protein phosphatase) knock-out … Webb1 apr. 2015 · Here we used PHLPP1 gene knockout (KO) mice to unambiguously authenticate target specificity of several common, as well as seldom used, PHLPP1 …
Physiological and pathological impact of AQP1 knockout in mice
WebbBone marrow derived mRNA profiles of wild-type and Phlpp1-/- mice were generated in duplicate. Contributor(s) Cohen Katsenelson K, Stender JD, Glass CK, Newton AC: Citation(s) 31408005: Submission date: Jun ... Phlpp1 Knockout KLA treatment 1h replicate 2: GSM3227930: Phlpp1 Knockout KLA treatment 24h replicate 1 Relations: … WebbMethods: Deletion of RelA/p65 in the liver was achieved using an inducible conditional knockout system (rela(F/F)MxCre mice) or, hepatocyte-specifically, using a … holidays on 1/19
PHLPP - an overview ScienceDirect Topics
Webb13 aug. 2024 · Additionally, mice lacking PHLPP1 have enhanced chondrocyte proliferation as a result of increased Akt2 activity, diminished FoxO1 levels, and increased Fgf18 expression, suggesting PHLPP1 inhibition could be a strategy to promote cartilage regeneration and repair ( Bradley et al., 2015 ). WebbDouble PHLPP1/PHLPP2 knockout mice are protected against induced colitis, showing decreased inflammation-induced apoptosis of intestinal epithelial cells, associated with … hulu prices increasing