Webb7 mars 2013 · Tigecycline clearance was reduced by approximately 20%, and area under the tigecycline concentration-time curve increased by approximately 30% in subjects … WebbEnterococci in the intestinal microflora were reduced, whereas the number of Enterobacteriaceae and Bacteroides remained relatively constant. Several strains of Bacteroides spp. resistant to tigecycline treatment …

Tigecycline 50 mg powder for solution for infusion

Webb29 dec. 2024 · 1. Introduction. Tigecycline (TGC) is the first member of the glycylcycline class of antimicrobial agents and is associated with refractory infections in critically ill … Webbaltered by hemodialysis. The pharmacokinetics of tigecycline are also not affected by food, although tolerability is increased if the drug is administered following a meal. … harry robinson buick fort smith ar

Tigecycline - Wikipedia

Tigecycline, a first-in-class glycylcycline antimicrobial agent, has an expanded spectrum of activity against gram-positive, gram-negative, aerobic, anaerobic, and atypical bacteria, including strains that are multidrug resistant. It is active against methicillin-resistant S. aureus, penicillin-resistant S. pneumoniae, … Visa mer Glycylcyclines are a novel class of antimicrobial agents, and tigecycline (figure 1) is the first of the glycylcyclines to reach the final stage of clinical development. Tigecycline inhibits translation of bacterial … Visa mer The pharmacokinetic properties of tigecycline have been studied in several animal species. Overall, the pharmacokinetics in animals is characterized by a low … Visa mer The pharmacokinetics of tigecycline, including metabolism and mass balance studies, have been evaluated in healthy subjects and in patients with complicated skin and skin-structure … Visa mer The interrelationship between the pharmacokinetics and pharmacodynamics of antimicrobial agents has become increasingly important. Data from in vitro and in vivo infection models, including dose fractionation … Visa mer WebbThe pharmacokinetic parameters of tigecycline were assessed in subjects with severe renal impairment (creatinine clearance <30 mL/min, n = 6), subjects receiving … Webb1 juli 2006 · The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, … charles p taft cincinnati