WebMay 10, 2024 · About TROP2 in Triple Negative Breast Cancer . TROP2 (trophoblast cell-surface antigen 2) is a transmembrane glycoprotein that is overexpressed in several types of solid tumors, including breast cancer . 4. Research indicates that high TROP2 expression is associated with cancer cell growth and proliferation and poor patient survival. 4, 5 WebApr 7, 2024 · BAT8008 是百奥泰开发的靶向 Trop2 的ADC，由重组人源化抗 Trop2 抗体与毒性小分子拓扑异构酶 I 抑制剂通过自主研发的可剪切连接子连接而成。 BAT8008 具有高效的抗肿瘤活性，毒素小分子有较强的旁观者效应，可有效克服肿瘤组织的异质性。
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WebMar 15, 2024 · Originally, the expression of Trop 2 was described in trophoblasts (placenta) and fetal tissues. Since the discovery of Trop 2 in placenta, it is suggested that Trop 2 may play a key role in tumor development as being involved in several growth-stimulatory signaling pathways. WebSep 20, 2016 · Trophoblast cell surface antigen 2 (TROP2), also known as GA733-1 or EGP-1 or TACSTD2, was a 36-kDa transmembrane glycoprotein, which was originally defined on normal and malignant trophoblast... sky studios osterley london
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WebTrop-2 plays a role in tumor progression by actively interacting with several key molecular signaling pathways traditionally associated with cancer development and progression. … WebMar 15, 2024 · Originally, the expression of Trop 2 was described in trophoblasts (placenta) and fetal tissues. Since the discovery of Trop 2 in placenta, it is suggested that Trop 2 … WebApr 14, 2024 · Abstract. EGFR is a well-established target for the treatment of many cancers. However, limitations encountered with current therapies, such as drug resistance and low cytotoxicity, indicate a need for alternative treatments. In particular, antibody-drug conjugates (ADCs) are a promising new therapeutic strategy, due to their potent killing … sky subscriber services livingston